Identification of disease markers associated to onset and progression of glioblastoma multiforme (GLIOMAS).
Glioblastoma multiforme (GBM) is one of the most aggressive and damaging tumors of the brain without effective targeted chemotherapeutic agents. To date, the poor understanding of the molecular mechanisms underlying GBM aggression, multiple drug resistance (MDR), and relapse have prevented the development of effective targeted therapies. The main goal of our study is to identify key biomarkers involved in hypoxia and stemness by studying their expression profiles in in Distinct GBM Areas Isolated by 5-Aminolevulinic acid Fluorescence-Guided Surgery